Freeze drying, also known as lyophilization, is a process that removes water from nanoparticles to improve their stability and shelf life. Ultrasonic spray technology is used for freeze drying of nanoparticles in pharmaceuticals, biotechnology, and diagnostics.
Sono-Tek ultrasonic spray systems have been used for freeze drying processes for decades. Ultrasonic spray is ideal for the creation of uniform micron sized droplets. Using ultrasonic spray, a liquid solution is atomized into a fine mist using ultrasonic waves, rapidly freezing the droplets in a liquified gas. Further drying them produces a dry powder with uniform particle size and high porosity. Ultrasonic atomization is a key step in the freeze-drying process, creating very small, evenly distributed particles, and contributing to long-term stability of nanoparticles.
Benefits of Sono-Tek systems for freeze drying include:
- Very tight droplet distribution create highly uniform sized particles, with choice of drop size, depending on nozzle frequency (down to ~13 microns)
- Very low pressure atomization allows manipulation of particle qualities, including morphology and porosity, without damaging fragile structures
- Excellent tool for R&D and laboratory environments
- Ability to atomize very small samples and at very low flow rates
- Non-clogging ultrasonic nozzles require little to no maintenance, with no moving parts to wear out
- Full coating solutions optimized for application specific needs
Visit https://www.sono-tek.com/ultrasonic-coating/how-ultrasonic-nozzles-work/ to learn more about the benefits of ultrasonic spray for freeze drying nanoparticles.